A personalized mRNA-based melanoma vaccine significantly reduced the risk of cancer recurrence or death
In a new clinical trial, a personalized mRNA-based melanoma vaccine reduced the risk of recurrence or death within two years by 42%.
The vaccine is custom-made to target the unique genetic mutations of each person’s melanoma, and is the first of its kind to show positive results in a phase III trial.
Of the trial patients who received the vaccine alongside an immunotherapy treatment, 82% were alive and recurrence-free after two years, compared to 70% who only received the traditional melanoma treatment.
Why is this good news? The vaccine’s success could have positive implications for other types of cancer, too, and one doctor said the findings were “a foundational shift in our approach to cancer” that had “not been achieved before in the history of cancer drug development.”
A record number of women are running for state legislatures in the US this year
In the 2026 midterm elections, a record 3,824 women are running for state legislatures across the 46 states with seats on the ballot, up from the previous record of 3,621 women candidates in 2022.
Women make up just over one-third of all state legislative candidates this midterm election cycle, and more than two-thirds of the candidates are Democrats.
While the U.S. currently has a record level of representation in state legislatures, about one-third, it’s nowhere near parity. Republicans also lag significantly behind, as about 64% of women in state legislatures are Democrats.
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